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In addition, analyses of disease-related genes of higher prevalence in the Ashkenazi Jewish population indicate that only a minority of traits show signs of positive selection, suggesting that most have arisen through random genetic drift.

[...] 'We were surprised to find evidence that Ashkenazi Jews have higher heterozygosity than Europeans, contradicting the widely-held presumption that they have been a largely isolated group,' says first author Steven Bray, Ph D, a postdoctoral fellow in Warren's laboratory.

"Abraham's Children in the Genome Era: Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry." The American Journal of Human Genetics 86:6 (June 3, 2010): pages 850-859.

Abstract: "For more than a century, Jews and non-Jews alike have tried to define the relatedness of contemporary Jewish people.

Our analysis indeed revealed higher European admixture than predicted from previous Y-chromosome analyses.

Moreover, we also show that admixture directly correlates with high LD, suggesting that admixture has increased both genetic diversity and LD in the AJ population.

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Also used for comparison were 3 Middle Eastern populations: Palestinian Arabs, Druze, and Bedouins.Additionally, we applied extended haplotype tests to determine whether positive selection can account for the level of AJ-prevalent diseases.We identified genomic regions under selection that account for lactose and alcohol tolerance, and although we found evidence for positive selection at some AJ-prevalent disease loci, the higher incidence of the majority of these diseases is likely the result of genetic drift following a bottleneck.The genomic analysis also provided information about selection pressures on mutations prevalent in the Ashkenazi Jewish population, such as those leading to conditions like Tay-Sachs disease or mutations in cancer susceptibility genes like BRCA1.

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[...]" Gil Atzmon, Li Hao, Itsik Pe'er, Christopher Velez, Alexander Pearlman, Pier Francesco Palamara, Bernice Morrow, Eitan Friedman, Carole Oddoux, Edward Burns, Harry Ostrer.[...] High linkage disequilibrium can come either from an isolated population (for example, an island whose residents are all descendents of shipwreck survivors) or the relatively recent mixture of separate populations.

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